Mainz v Hoffenheim Bet Builder, Tips and Predictions | Bundesliga

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DavidParsons

David Parsons is an experienced sports writer with over 15 years’ expertise, creating trusted, data-driven match previews and betting content for leading sports platforms.

Published Date: November 20, 2025 10:17 AM

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Mainz v Hoffenheim Match Preview

Mainz v Hoffenheim Bet Builder, Tips and Predictions – Bundesliga | 21 Nov, 19:30

Venue: MEWA Arena
Competition: Bundesliga
Kick-Off: Friday 21st November 2025 – 19:30 (UK)

Mainz v Hoffenheim Preview

Friday night Bundesliga action returns with a clash at the MEWA Arena as struggling Mainz welcome in-form Hoffenheim to open the weekend’s fixtures. The two teams are heading in very different directions, and this game could be another goal-heavy affair.

Mainz entered the international break on a sour note after a narrow 1-0 defeat away to Eintracht Frankfurt, leaving them 17th in the Bundesliga with just one win from their opening 11 games. Bo Henriksen’s side have been competitive in Europe — winning all three of their Conference League games — but their domestic struggles are a growing concern.

The 05ers have at least shown signs of life in front of goal recently, scoring in their last two home fixtures. With attacking threats like Lee Jae-Sung and Brajan Gruda, Mainz certainly have the weapons to trouble Hoffenheim — even if their defensive consistency remains a major issue.

By contrast, Hoffenheim are flying high and full of confidence. Christian Ilzer’s side made it four Bundesliga wins on the trot before the break, beating St. Pauli (3-0), Heidenheim (3-1), Wolfsburg (3-2) and RB Leipzig (3-1) — scoring 12 goals across that run.

The visitors also boast one of the league’s strongest away records, unbeaten in five on the road (W4, D1), and have netted at least twice in every away match this season.

With Mainz vulnerable defensively and Hoffenheim in prolific form, this looks tailor-made for another both teams to score outcome — and the in-form visitors to edge it.

Mainz v Hoffenheim

21 Nov 19:30 - Mainz 05 vs Hoffenheim - Bundesliga

21 Nov 19:30
Mainz 05 vs Hoffenheim - Bundesliga

Hoffenheim Win

Match Result

7/4

Reason for Tip

Mainz v Hoffenheim Bet Builder, Tips and Predictions – Bundesliga | 21 Nov, 19:30

Venue: MEWA Arena
Competition: Bundesliga
Kick-Off: Friday 21st November 2025 – 19:30 (UK)

Mainz v Hoffenheim Preview

Friday night Bundesliga action returns with a clash at the MEWA Arena as struggling Mainz welcome in-form Hoffenheim to open the weekend’s fixtures. The two teams are heading in very different directions, and this game could be another goal-heavy affair.

Mainz entered the international break on a sour note after a narrow 1-0 defeat away to Eintracht Frankfurt, leaving them 17th in the Bundesliga with just one win from their opening 11 games. Bo Henriksen’s side have been competitive in Europe — winning all three of their Conference League games — but their domestic struggles are a growing concern.

The 05ers have at least shown signs of life in front of goal recently, scoring in their last two home fixtures. With attacking threats like Lee Jae-Sung and Brajan Gruda, Mainz certainly have the weapons to trouble Hoffenheim — even if their defensive consistency remains a major issue.

By contrast, Hoffenheim are flying high and full of confidence. Christian Ilzer’s side made it four Bundesliga wins on the trot before the break, beating St. Pauli (3-0), Heidenheim (3-1), Wolfsburg (3-2) and RB Leipzig (3-1) — scoring 12 goals across that run.

The visitors also boast one of the league’s strongest away records, unbeaten in five on the road (W4, D1), and have netted at least twice in every away match this season.

With Mainz vulnerable defensively and Hoffenheim in prolific form, this looks tailor-made for another both teams to score outcome — and the in-form visitors to edge it.

21 Nov 19:30 - Mainz 05 vs Hoffenheim - Bundesliga

21 Nov 19:30
Mainz 05 vs Hoffenheim - Bundesliga

BTTS - Yes

Both Teams To Score

5/9

Reason for Tip

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Current Form Guide

Mainz have scored in their last 2 home games

Hoffenheim have won their last 4 games on the trot

Hoffenheim still remain unbeaten away from home

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Team News and Predicted Line-Ups

Mainz

Out: Caci (hamstring), Dal (knee).
Doubtful: Amiri (adductor).
Key Players: Lee Jae-Sung, Amiri, Hollerbach.

Predicted XI:
Zentner; Da Costa, Maloney, Kohr; Widmer, Sano, Amiri, Mwene; Nebel, Lee; Hollerbach

Hoffenheim

Out: None major.
Key Players: Andrej Kramaric, Baumann, Promel.
Note: Oliver Baumann set for his 500th Bundesliga appearance.

Predicted XI:
Baumann; Coufal, Hranac, Hajdari, Bernardo; Promel, Avdullahu, Burger; Kramaric; Lemperle, Toure

Mainz v Hoffenheim Prediction

Mainz are fighting to find form domestically, but Hoffenheim’s current momentum looks unstoppable. With both sides capable of finding the net but Hoffenheim boasting far greater firepower, this clash should deliver goals — and another victory for the visitors.

Mainz v Hoffenheim Betting Tips

TipMan Bet Builder

Bet Builder:
✅ Both Teams To Score – YES
✅ Hoffenheim Win

💥 Combined Odds: 4.00 (Betfred)

Mainz v Hoffenheim

21 Nov 19:30 - Mainz 05 vs Hoffenheim - Bundesliga

21 Nov 19:30
Mainz 05 vs Hoffenheim - Bundesliga

Hoffenheim Win

Match Result

7/4

Reason for Tip

Mainz v Hoffenheim Bet Builder, Tips and Predictions – Bundesliga | 21 Nov, 19:30

Venue: MEWA Arena
Competition: Bundesliga
Kick-Off: Friday 21st November 2025 – 19:30 (UK)

Mainz v Hoffenheim Preview

Friday night Bundesliga action returns with a clash at the MEWA Arena as struggling Mainz welcome in-form Hoffenheim to open the weekend’s fixtures. The two teams are heading in very different directions, and this game could be another goal-heavy affair.

Mainz entered the international break on a sour note after a narrow 1-0 defeat away to Eintracht Frankfurt, leaving them 17th in the Bundesliga with just one win from their opening 11 games. Bo Henriksen’s side have been competitive in Europe — winning all three of their Conference League games — but their domestic struggles are a growing concern.

The 05ers have at least shown signs of life in front of goal recently, scoring in their last two home fixtures. With attacking threats like Lee Jae-Sung and Brajan Gruda, Mainz certainly have the weapons to trouble Hoffenheim — even if their defensive consistency remains a major issue.

By contrast, Hoffenheim are flying high and full of confidence. Christian Ilzer’s side made it four Bundesliga wins on the trot before the break, beating St. Pauli (3-0), Heidenheim (3-1), Wolfsburg (3-2) and RB Leipzig (3-1) — scoring 12 goals across that run.

The visitors also boast one of the league’s strongest away records, unbeaten in five on the road (W4, D1), and have netted at least twice in every away match this season.

With Mainz vulnerable defensively and Hoffenheim in prolific form, this looks tailor-made for another both teams to score outcome — and the in-form visitors to edge it.

21 Nov 19:30 - Mainz 05 vs Hoffenheim - Bundesliga

21 Nov 19:30
Mainz 05 vs Hoffenheim - Bundesliga

BTTS - Yes

Both Teams To Score

5/9

Reason for Tip

Select Stake:

£1.00

£5.00

£10.00

£20.00

£50.00

Conclusion

Mainz will have their moments in front of goal, but Hoffenheim’s attacking depth, confidence, and away form make them the likelier winners. Expect an entertaining fixture at the MEWA Arena with goals at both ends — and Hoffenheim to extend their winning streak.

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