Napoli vs Pisa: Preview, Predictions & Tips | Serie A

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Lucio Pollice

Football fanatic and data-driven tipster who heads up Tipman’s Daily Doubles, as well as key free and premium football tips. With over two years of profitable tracked results, he blends stats and instinct to deliver consistent value for punters.

Published Date: September 21, 2025 9:55 PM

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Match Info

Competition: Serie A 2025/26
Date: Monday, 22 September 2025
Venue: Stadio Diego Armando Maradona, Naples
Kick-off: 19:45 UK time

Napoli host Pisa in a Monday night clash which will see the defending champions looking for their fourth league win after a disappointing european night.

napoli vs pisa prediction

22 Sep 19:45 - Napoli vs Pisa - Serie A

22 Sep 19:45
Napoli vs Pisa - Serie A

Napoli (-1)

Match Result with Handicap -1

5/6

Reason for Tip

Given their strong home form and the contrast in recent performances, Napoli are clear favourites. Pisa remain without a goal in several games and face an uphill battle when defending away at a stadium where the hosts have been nearly flawless.

22 Sep 19:45 - Napoli vs Pisa - Serie A

22 Sep 19:45
Napoli vs Pisa - Serie A

Kevin De Bruyne to Score or Assist

Player To Score Or Assist

22/25

Reason for Tip

De Bruyne has been incisive since the start of the season and is central to Napoli’s creative and attacking play. He created chances, scored, and will likely be trusted again to influence the match via goal or assist. He’ll also want to make an impact given he was sacrificed against Man City when his teammate got sent off early in the game.

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Current Form and recent matches

Napoli
Napoli are off to another strong start in Serie A, having won their first three matches. The defending champions showed attacking fluidity and defensive solidity—just one goal conceded so far. Their perfect league record, however, stumbled in Europe after a 2-0 defeat to Manchester City; still, Antonio Conte’s side will be eager to bounce back at home. Additionally, Napoli have been excellent at the Diego Armando Maradona Stadium: they are unbeaten in their last 12 home Serie A matches (9 wins, 3 draws) and have kept a clean sheet in half of those.

Pisa
Pisa’s season has so far been bleak. After three matches, they have recorded just one point (one draw, two defeats) and remain goalless for two games running. They lost narrowly at home to Udinese in their most recent fixture. Pisa face a difficult task here: they’ve played multiple games already this season against teams who qualified for European competitions last year, and this Napoli match is seen by many as their toughest opened fixture at home so far.

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Our Prediction

Napoli to Win -1
Given their strong home form and the contrast in recent performances, Napoli are clear favourites. Pisa remain without a goal in several games and face an uphill battle when defending away at a stadium where the hosts have been nearly flawless.

Kevin De Bruyne 1+ Goal or Assist
De Bruyne has been incisive since the start of the season and is central to Napoli’s creative and attacking play. He created chances, scored, and will likely be trusted again to influence the match via goal or assist.

Napoli’s quality, momentum, and home advantage make them well placed to dominate. Pisa are under pressure and haven’t found their scoring rhythm. Expect Napoli to win comfortably, likely without conceding.

Predicted score: Napoli 2-0 Pisa

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napoli vs pisa prediction

22 Sep 19:45 - Napoli vs Pisa - Serie A

22 Sep 19:45
Napoli vs Pisa - Serie A

Napoli (-1)

Match Result with Handicap -1

5/6

Reason for Tip

Given their strong home form and the contrast in recent performances, Napoli are clear favourites. Pisa remain without a goal in several games and face an uphill battle when defending away at a stadium where the hosts have been nearly flawless.

22 Sep 19:45 - Napoli vs Pisa - Serie A

22 Sep 19:45
Napoli vs Pisa - Serie A

Kevin De Bruyne to Score or Assist

Player To Score Or Assist

22/25

Reason for Tip

De Bruyne has been incisive since the start of the season and is central to Napoli’s creative and attacking play. He created chances, scored, and will likely be trusted again to influence the match via goal or assist. He’ll also want to make an impact given he was sacrificed against Man City when his teammate got sent off early in the game.

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Head-to-Head & Key Trends

Napoli have never been defeated by Pisa when defending their Scudetto: in Serie A, Pisa have historically had poor results versus the reigning champions.

The two clubs’ last match in an official competition was in 2007 in Coppa Italia, where Napoli won 3-1.

Napoli have scored first in 15 of their last 20 home league fixtures.

Pisa are the only Serie A team so far not to have scored in any second half of matches.

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Key Players & Absences

Kevin De Bruyne (Napoli): After scoring two goals in three Serie A matches, he’ll be looking to build on his fine start and respond after the tough outing in the Champions League.
Stefano Moreo (Pisa): While Pisa haven’t scored much, Moreo tends to appear in the opening phases of matches and has scored the opener in many of the few games he appears in.
Unavailable players: Napoli will be without Amir Rrahmani. Pisa will be missing Juan Cuadrado due to suspension/ineligibility.

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Free Bets & Offers

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napoli vs pisa prediction

22 Sep 19:45 - Napoli vs Pisa - Serie A

22 Sep 19:45
Napoli vs Pisa - Serie A

Napoli (-1)

Match Result with Handicap -1

5/6

Reason for Tip

Given their strong home form and the contrast in recent performances, Napoli are clear favourites. Pisa remain without a goal in several games and face an uphill battle when defending away at a stadium where the hosts have been nearly flawless.

22 Sep 19:45 - Napoli vs Pisa - Serie A

22 Sep 19:45
Napoli vs Pisa - Serie A

Kevin De Bruyne to Score or Assist

Player To Score Or Assist

22/25

Reason for Tip

De Bruyne has been incisive since the start of the season and is central to Napoli’s creative and attacking play. He created chances, scored, and will likely be trusted again to influence the match via goal or assist. He’ll also want to make an impact given he was sacrificed against Man City when his teammate got sent off early in the game.

Select Stake:

£1.00

£5.00

£10.00

£20.00

£50.00

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